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KMID : 1007520150240062205
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Food Science and Biotechnology
2015 Volume.24 No. 6 p.2205 ~ p.2212
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Hepatoprotective Effect of Diospyros lotus Leaf Extract against Acetaminophen-induced Acute Liver Injury in Mice
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Cho Byoung-Ok
Yin Hong-Hua
Fang Chong-Zhou
Kim Sang-Jun
Jeong Seung-Il
Jang Seon-Il
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Abstract
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The aim of this study was to investigate the protective effect of Diospyros lotus leaf extract (DLE) against acetaminophen (APAP)-induced acute liver injury in mice. Administration of DLE significantly attenuated the levels of serum aspartate aminotransferase, alanine aminotransferase, and liver lipid peroxidation in APAP-treated mice. Histopathological examination showed that DLE treatment decreased the incidence of liver lesions in APAP-treated mice. DLE treatment markedly increased superoxide dismutase, catalase, glutathione peroxidase activity, and glutathione levels in APAP-treated mice. Furthermore, DLE treatment significantly suppressed the production of proinflammatory factors such as the nitric oxide, IL-6, TNF-α, and iNOS in APAP-treated mice. These results suggest that DLE protects the liver from APAP-induced hepatic injury via antioxidant and antiinflammatory effects.
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KEYWORD
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Diospyros lotus, acetaminophen, liver injury, antioxidants, anti-inflammation
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